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生命科学学院丁丹研究员Nature Communications，通讯作者：丁丹，Ben Zhong Tang Nature Communications volume 10, Article number: 768 (2019) 10.1038/s41467-019-08722-z https://www.nature.com/articles/s41467-019-08722-z 南开共同通讯&并列一作
Highly efficient photothermal nanoagent achieved by harvesting energy via excited-state intramolecular motion within nanoparticles Zheng Zhao, Chao Chen, Wenting Wu, Fenfen Wang, Lili Du, Xiaoyan Zhang, Yu Xiong, Xuewen He, Yuanjing Cai, Ryan T. K. Kwok, Jacky W. Y. Lam, Xike Gao, Pingchuan Sun, David Lee Phillips, Dan Ding* & Ben Zhong Tang*
Affiliations Department of Chemistry, The Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, Institute of Molecular Functional Materials, Division of Life Science and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, 999077, China Zheng Zhao, Xuewen He, Yuanjing Cai, Ryan T. K. Kwok, Jacky W. Y. Lam & Ben Zhong Tang State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, Ministry of Education, and College of Life Sciences, Nankai University, Tianjin, 300071, China Chao Chen, Xiaoyan Zhang & Dan Ding Key Laboratory of Synthetic and Self-assembly Chemistry for Organic Functional Molecules, Shanghai Institute of Organic Chemistry, Chinese Academy of Science, 345 Lingling Road, Shanghai, 200032, China Wenting Wu & Xike Gao Key Laboratory of Functional Polymer Materials, Ministry of Education, College of Chemistry, Nankai University, Tianjin, 300071, China Fenfen Wang & Pingchuan Sun Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, 000000, China Lili Du & David Lee Phillips Institute of Life Sciences, Jiangsu University, Zhenjiang, 212013, China Lili Du Guangdong Provincial Key Laboratory of Brain Science, Disease and Drug Development, Shenzhen Research Institute, No. 9 Yuexing 1st RD, South Area, Hi-tech Park, Nanshan, Shenzhen, 518057, China Yu Xiong & Ben Zhong Tang These authors contributed equally: Zheng Zhao, Chao Chen, Wenting Wu. Correspondence to Dan Ding or Ben Zhong Tang.
Abstract The exciting applications of molecular motion are still limited and are in urgent pursuit, although some fascinating concepts such as molecular motors and molecular machines have been proposed for years. Utilizing molecular motion in a nanoplatform for practical application has been scarcely explored due to some unconquered challenges such as how to achieve effective molecular motion in the aggregate state within nanoparticles. Here, we introduce a class of near infrared-absorbing organic molecules with intramolecular motion-induced photothermy inside nanoparticles, which enables most absorbed light energy to dissipate as heat. Such a property makes the nanoparticles a superior photoacoustic imaging agent compared to widely used methylene blue and semiconducting polymer nanoparticles and allow them for high-contrast photoacoustic imaging of tumours in live mice. This study not only provides a strategy for developing advanced photothermal/photoacoustic imaging nanoagents, but also enables molecular motion in a nanoplatform to find a way for practical application.
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发表于 2019-2-12 09:13:56
