管坤良：修订间差异

2016年12月25日 (日) 18:44的最新版本

管坤良 Kun-Liang Guan

浙江大学生命科学研究院兼职教授、共同院长

教育背景
1978-1982 杭州大学生物学学士学位
1983-1989 美国普渡大学（Purdue University）生物化学博士
1989-1991 美国普渡大学（Purdue University）生物化学博士后
工作经历
1992-2007 美国密歇根大学（University of Michigan）生物化学系助理教授、副教授、教授
2002-2007 美国密歇根大学（University of Michigan）生命科学研究院Halvor Christensen 教授
2007-至今美国加州大学圣地亚哥分校（UCSD）药学系教授

学术奖项与活动 1989 The Arnold Kent Balls Award, Department of Biochemistry, Purdue University
1998-2003 MacArthur Fellow, The John D. Catherine T. MacArthur Foundation
1999 Schering-Plough Award (Young Investigator Award), American Society
of Biochemistry and Molecular Biology
1999 Yong Investigator Award, Society of Chinese Bioscientist Association
April 1999 Procter & Gamble Lecture, Purdue University
April 2004 Susan Swerling Lecture, Dana-Farber Cancer Institute, Harvard Medical School
2004 Faculty Recognition Award, University of Michigan
2006 Distinguished Alumni Award, Purdue University Agriculture School
1995-1999 Panel member of the NSF cell biology study section
1997-2002 Editorial board member, Journal of Biological Chemistry
1999-2002 Editorial board member, Biological Signals and Receptors
2005- Editorial board member, Experimental & Mol. Medicine
1998 NIH Study Section, Molecular Biology (Ad Hoc)
1999-2003 NIH Study Section, CDF-3
2003-2006 中国国家自然科学基金委员会评审委员

研究方向
细胞生长调节及肿瘤细胞生物学的信号转导研究
Signal transduction in cell growth regulation and cancer cell biology

http://profiles.ucsd.edu/kun-liang.guan
http://lsi.zju.edu.cn/yjdw_dsjs_detail.aspx?ID=2

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-&nbsp;管坤良博士<br>浙江大学生命科学研究院兼职教授、共同院长<br>电话：0571-88981336<br>传真：0571-88981337<br>Email: lsi@zju.edu.cn (公务); kuguan@ucsd.edu (个人)<br>
+管坤良 Kun-Liang Guan
+<br>
-教育背景 <br>1978-1982 杭州大学生物学学士学位 <br>1983-1989 美国普渡大学（Purdue University）生物化学博士 <br>1989-1991 美国普渡大学（Purdue University） 生物化学博士后
+<br>浙江大学生命科学研究院兼职教授、共同院长
+<br>
-工作经历 <br>1992-2007 美国密歇根大学（University of Michigan）生物化学系助理教授、副教授、教授 <br>2002-2007 美国密歇根大学（University of Michigan）生命科学研究院Halvor Christensen 教授 <br>2007-至今 美国加州大学圣地亚哥分校（UCSD）药学系教授<br>详细介绍：<br>学术奖项与活动
+<br>教育背景
+<br>1978-1982 杭州大学生物学学士学位 <br>1983-1989 美国普渡大学（Purdue University）生物化学博士 <br>1989-1991 美国普渡大学（Purdue University） 生物化学博士后
+<br>
+工作经历 <br>1992-2007 美国密歇根大学（University of Michigan）生物化学系助理教授、副教授、教授 <br>2002-2007 美国密歇根大学（University of Michigan）生命科学研究院Halvor Christensen 教授 <br>2007-至今 美国加州大学圣地亚哥分校（UCSD）药学系教授<br>
+<br>
+<br>学术奖项与活动
 The Arnold Kent Balls Award, Department of Biochemistry, Purdue University<br>1998-2003 MacArthur Fellow, The John D. Catherine T. MacArthur Foundation <br>1999 Schering-Plough Award (Young Investigator Award), American Society <br> of Biochemistry and Molecular Biology<br>1999 Yong Investigator Award, Society of Chinese Bioscientist Association<br>April 1999 Procter &amp; Gamble Lecture, Purdue University<br>April 2004 Susan Swerling Lecture, Dana-Farber Cancer Institute, Harvard Medical School<br>2004 Faculty Recognition Award, University of Michigan<br>2006 Distinguished Alumni Award, Purdue University Agriculture School<br>1995-1999 Panel member of the NSF cell biology study section <br>1997-2002 Editorial board member, Journal of Biological Chemistry <br>1999-2002 Editorial board member, Biological Signals and Receptors <br>2005- Editorial board member, Experimental &amp; Mol. Medicine <br>1998 NIH Study Section, Molecular Biology (Ad Hoc) <br>1999-2003 NIH Study Section, CDF-3<br>2003-2006 中国国家自然科学基金委员会 评审委员<br>
+<br>
-研究方向
+<br>研究方向
+<br>
 细胞生长调节及肿瘤细胞生物学的信号转导研究 <br>Signal transduction in cell growth regulation and cancer cell biology
-代表性论文 <br> <br>1.Inoki, K., Ouyang, H., Zhu, T., Lindvall, C., Wang, Y., Yang, Q., Bennett, C., Harada, Y., Stankunas, K., Wang, C., He, H., MacDougald, O., You, M., Williams, B., and Guan, K-L. (2006) TSC2 integrates Wnt and cellular energy signals through a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth. Cell 126, 955-68. 【PDF download】<br> <br>2.Aurandt, J, Li., W., and Guan, K-L. (2006) Semaphorin-4D activates the MAPK pathway downstream of plexin-B1. Biochem. J. 394, 459-64. 【PDF download】<br> <br>3.Li, W., Aurandt, J., Jürgensen, C., Rao, Y., and Guan, K-L. (2006) FAK and Src kinases are required for netrin-induced tyrosine phosphorylation of UNC5. J. Cell Science. 119, 47-55. 【PDF download 】<br> <br>4.Chong-Kopera, H., Inoki, K., Li, Y., Zhu, T., Garcia-Gonzalo, F.R., Rosa, J.L., and Guan, K-L. (2006) TSC1 stabilizes TSC2 by inhibiting the interaction between TSC2 and the HERC1 ubiquitin ligase. J. Biol. Chem. 281, 8313-6. 【PDF download】<br> <br>5.Yang, Q., Inoki, K, Kim, E., and Guan, K-L. (2006) TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activity. Proc. Natl. Acad. Sci. USA 103(18):6811-6. 【PDF download】<br> <br>6.Inoki, K. and Guan, K-L. (2006) .Complexity of the TOR signaling network. Trends in Cell Biol. 16, 206-12. 【PDF download】<br> <br>7.Corradetti, M. and Guan, K-L. (2006) Upstream of the mammalian target of rapamycin: do all roads pass through mTOR? Oncogene. 25, 6347-60. 【PDF download】<br> <br>8.Yang, Q., Inoki, K., Ikenoue, T., and Guan, K-L. (2006) Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity. Genes &amp; Dev. 20, 2820-32. 【PDF download】<br> <br>9.Zhao, B., Wei, X., et al and Guan, K-L. (2007) Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. Genes &amp; Development. 21, 2747-61. 【PDF download】<br> <br>10.Lee, CH, Inoki, K., Karbowniczek, M, Petroulakis, E, Sonenberg, N, Henske, EP, and Guan, K-L. (2007) .Constitutive mTOR activation in TSC mutants sensitizes cells to energy starvation and genomic damage via p53. The EMBO J. 26, 4812-23. 【PDF download】<br> <br>11.Li, Y., Wang, Y., Kim, E., Beemiler, P., Wang, C-Y., Swanson, J., You, M., and Guan, K-L. (2007) Bnip3 mediates the hypoxia-induced inhibition on mTOR by interacting with Rheb. J. Biol. Chem. 282, 35803-13. 【PDF download】<br> <br>12.Lee, C.J, Inoki, K., and Guan, K-L. (2007) mTOR Pathway as a Target in Tissue Hypertrophy. Annu. Rev. Pharmacol. Toxicol. 47, 443-67. 【PDF download】<br> <br>13.Yang, Q. and Guan, K-L. (2007) Expanding mTOR signaling. Cell Research. 17, 666-681. 【PDF download】<br> <br>14.Lei, QY., Zhang, H., Zhao, B., Zha, Y., Bai, F., Pei, XH., Zhao, S., Xiong, Y., and Guan, K-L., (2008) TAZ promotes cell proliferation and EMT and is inhibited by the Hippo pathway. Mol. Cell Biol. 28, 2426-36. 【PDF download】<br> <br>15.Zhao, B., Ye, X., Yu, J., Li, L., Li, W., Li, S., Lin, JD., Wang, C-Y., Chinnaiyan, AM., Lai, Z-C., and Guan. K-L. (2008) TEAD mediates YAP dependent gene induction and growth control. Genes &amp; Development, 22, 1962-71. 【PDF download】<br> <br>16.Ikenoue, T., Inoki, K., Yang, Q., Zhou, X, and Guan, K-L. (2008) Essential Function of TORC2 in PKC and Akt Turn Motif Phosphorylation, Maturation, and Signaling. EMBO J. 27, 1919-1931. 【PDF download】<br> <br>17.Kim, E., Goraksha, P., Li, L., Neufeld, T.P., and Guan, K-L. (2008) Regulation of TORC1 by Rag GTPases in nutrient response. Nature Cell Biol. 10, 935-945 【PDF download】<br> <br>18.Ikenoue, T., Inoki, K., Zhao, B., and Guan, K-L. (2008) PTEN Acetylation Modulates its Interaction with PDZ Domain. Cancer Research, 68, 6908-12. 【PDF download】<br> <br>19.Zhao, B., Lei, Q.Y., and Guan, K-L. (2008) The Hippo-YAP pathway: new connections between regulation of organ size and cancer. Current Opinion in Cell Biology. 20, 638-646. 【PDF download】<br> <br>20.Zhao, S. and Guan, K-L. (2008) Substrate selectivity APPLies to Akt. Cell. 133, 399-400. 【PDF download】<br> <br>21.Zhao, B., Kim, J., Ye, X., Lai, Z-C, and Guan, K-L. (2009) Both TEAD binding and WW domains are required for the growth stimulation and oncogenic transformation activity of YAP. Cancer Research. 69, 1089-1098. 【PDF download】<br> <br>22.Mori, H., Inoki, K., Münzberg, H., Opland, D., Faouzi, M., Villanueva, E.C., Ikenoue, T., Kwiatkowski, D., MacDougald, O.A., Myers, M.G. Jr., and Guan, K-L. (2009) Critical role for hypothalamic mTOR activity in energy balance. Cell Metabolism. 9, 362-74. 【PDF download】<br> <br>23.Zhao, S., Lin, Y., Xu., W., Jiang, W., Zha, Z., Wang, P., Yu, W., Li, Z., Gong, L., Peng, Y., Ding, J., Lei, Q., Guan, K-L., Xiong, Y. (2009) Glioma-derived Mutations in IDH1 Dominantly Inhibit IDH1 Catalytic Activity and Induce HIF-1a. Science. 324, 261-5. 【PDF download】<br> <br>24.Kim, E. and Guan, K-L. (2009) RAG GTPases in Nutrient-mediated TOR Signaling Pathway. Cell Cycle. 8, 1014-1018. 【PDF download】<br> <br>25.Inoki, K. and Guan, K-L. (2009) Tuberous sclerosis complex, implication from a rare genetic disease to common cancer treatment. Human Molecular Genetics. 18, R94-100. 【PDF download】<br> <br>26.Yu, W., Lin, Y., Yao, J., Huang, W., Lei, Q., Xiong Y., Zhao, S., and Guan, K-L. (2009) Lysine 88 Acetylation Negatively Regulates Ornithine Carbamoyltransferase Activity in Response to Nutrient Signals. J. Biol. Chem. 284, 13669-75. 【PDF download】<br> <br>27.Zhang, H., Liu-CY, Zha, ZY., Zhao, B., Yao, J., Zhao, SM., Xiong, Y., Lei, QY., and Guan, K-L. (2009) TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition. J. Biol. Chem. 284, 13355-62. 【PDF download】<br> <br>28.Zhao, B., Lei, Q., and Guan, K-L. (2009) Harness the Power: New Insights into the Inhibition of YAP/ Yorkie. Dev. Cell. 16, 321-322. <br> <br>29.Li, L. and Guan, K-L. (2009) Amino acid signaling to TOR activation: Vam6 functioning as a Gtr1 GEF. Mol. Cell 35, 543-545. 【PDF download】<br> <br>30.Zhao, B., Lei, Q., and Guan, K-L. (2009) MST Out and HCC In. Cancer Cell.16, 363-364. 【PDF download】<br> <br>31.Zhou, X., Ikenoue, T., Chen, X., Li, L., Inoki, K., and Guan, K-L. (2009) Rheb controls misfolded protein metabolism by inhibiting aggresome and autophagy. Proc. Nat. Acad. Sci. 106, 8923-8. 【PDF download】<br> <br>32. Mori, H., Inoki, K., Opland, D., Münzberg, H., Villanueva, EC., Faouzi, M., Ikenoue, T., Kwiatkowski, D., MacDougald, OA., Myers, MG., and Guan, K-L. (2009) Critical roles for the TSC-mTOR pathway in ?-cell function. American J. Physiol. Endocrinol Metab 297, E1013-1022.
+http://profiles.ucsd.edu/kun-liang.guan<br>
-. Zhao, B., Li, L., Wang, C-Y, and Guan, K-L. (2010) A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF?-TRCP, Genes &amp; Dev. 24, 72-85.
-. Zhang, X., Li, Y., Liu, K., Wang, F., Eathman J.L., Lee, C-H., Patrene, K., Eoodman, G.D., InoKi, K., MacDougald, OA., Guan, K-L. and Ouyang, H. (2010) Wnt/GSK3 signaling regulates ATF4 and its implication in canonical Wnt signaling-induced osteogenesis. J. Clin. Inves. (accepted).
-. Li, Z., Zhao, B., Wang, P., Chen, F., Dong, Z., Yang, H., Guan, K-L., and Xu, Y. (2010) Structural insights into the YAP and TEAD complex. Genes &amp; Dev. 24, 235-240.
-. Zhao, S., Xu, W., Jiang, W., Yu, W., Lin, Y., Zhang, T., Yao, J., Zeng, Y., Li, H., Li, Y., Shi., J., An, W., Hancock, S.M., He., F., Qin, L., Chin, J., Yang, P., Chen, X., Lei, Q., Xiong, Y., Guan, K-L., (2010) Regulation of cellular metabolism by protein lysine acetylation. Science 327, 1000-1004.
-. Wang, Q., Zhang, Y., Yang, C., Xiong, H., Lin, Y., Yao, J., Li, H., Xie, L., Zhao, W., Yao, Y., Ning, Z-B., Zeng, R., Xiong, Y., Guan, K-L., Zhao, S., Zhao, G-P. (2010) Acetylation of metabolic enzymes coordinates carbon source utilization and metabolic flux. Science 327, 1004-1007.
-. Alexander, A., Cai, SL., Kim, J., Nanez, A., Sahin, M., MacLean, KH., Inoki, K., Guan, K-L., Shen, J., Person, MD., Kusewitt, D., Mills., GB., Kastan, MB., Walker, CL. (2010) ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS. Proc. Nat. Acad. Sci. 107, 4153-8.
-. Liang I., Kim, J., Okazawa, H., Zhao, J., Zhao, B., Yu, J., Chinnaiyan, A., Israel, M., Goldstein, L., Abujarour, R., Ding, S., and Guan, K-L. (2010). The role of YAP transcription co-activator in regulating stem cells self-renewal and differentiation. Genes &amp; Dev. 24, 1106-1118.
-. Li, L., Kim, E., Yuan, H., Inoki, K., Goraksha-Hicks, Schiesher, R. L., Neufeld, T.P., Guan, K-L., (2010) Regulation of mTORC1 by the Rab and ARF GTPases. J. Biol. Chem. 285, 19705-9.
-. Kang, Y.J., Lu, M-K., and Guan, K-L. (2010) The TSC1 and TSC2 tumor suppressors are required for proper ER stress response and protect cells from ER stress-induced apoptosis. Cell Death &amp; Differentiation. (in press).
-. Guan, K-L., Yu, W., Lin, Y., Xiong, Y., Zhao, S. (2010) Generation of acetyllysine antibodies and affinity enrichment of acetylated peptides. Nature Protocol (in press).
-. Wang, C., Yoo, Y., Fan, H., Kim, E., Guan, K-L., and Guan, J-L. (2010) Regulation of integrin ?1 recycling to lipid rafts by Rab1a to promote cell migration. J. Biol. Chem. (in press).
-. Zhang, D., Contu, R., Latronico, MV., Zhang, J.L, Rizzi, R, Catalucci, D., Miyamoto, S., Huang K, Ceci, M., Gu, Y., Dalton, N.D., Peterson, K.L, Guan, K-L., Brown, J.H, Chen, J., Sonenberg, N., Condorelli, G. (2010) MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice. J. Clin. Invest. (in press).
 http://lsi.zju.edu.cn/yjdw_dsjs_detail.aspx?ID=2